Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
نویسندگان
چکیده
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
منابع مشابه
Japanese genome‐wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14
Genome-wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying single nucleotide polymorphisms (SNP) connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especiall...
متن کاملGenome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese
Genome-wide association studies (GWAS) have reported a number of loci harboring common variants that influence risk of colorectal cancer (CRC) in European descent. But all the SNPs identified explained a small fraction of total heritability. To identify more genetic factors that modify the risk of CRC, especially Chinese Han specific, we conducted a three-stage GWAS including a screening stage ...
متن کاملA new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer
Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. To identify novel CRC susceptibility loci, we conducted a new GWAS and performed a meta-analysis with five published GWAS (totalling 7,577 cases and 9,979 controls of European ancestry), i...
متن کاملCommentary: Two-sample Mendelian randomization: opportunities and challenges
A et al. Body mass index and lung cancer risk: results from the ICARE study, a large, population-based case-control study. A et al. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Anthropometric factors and ovarian cancer risk: a systematic review and nonlinear dose-response meta-analysis of prospective studies. Association of oral contraceptive use,...
متن کاملGenome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~ 4% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of GWAS, comprising 5,748 breast cancer cases and 8,084 controls together with 46,785 cases and 42,892 controls from 4 studies ge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Nature communications
دوره 6 شماره
صفحات -
تاریخ انتشار 2015